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Peg Dmg

The zeta potentials of adriamycin-encapsulating liposomes containing 1-(monomethoxy polyethyl-eneglycol)-2,3-dimyristoylglycerol (PEG-DMG) were measured in an isotonic solution of 10mM lactate buffer (pH 4.0) with sodium chloride and sucrose. The negativity of the zeta potentials of adriamycin-encapsulating liposomes containing PEG-DMG decreased with increases in NaCl concentration more steeply than that of adriamycin-encapsulating liposomes without PEG coating. From this observation, the electrical potential distributions near the membrane surfaces were shown to be different between adriamycin-encapsulating liposomes with and without PEG coating. Based on these zeta potential data, the thickness of the fixed aqueous layer around PEG-DMG-containing adriamycin liposomes was determined from the slope of In zeta potential versus Debye-Hiickel parameter plot. As a result, a correlation was indicated to exist between the circulation time of liposomes and the thickness of the aqueous layer around the liposomes.

KEY WORDS:: Adriamycin, aqueous layer thickness, polyethyleneglycol, reticuloendothelial system, zeta potential

Home Products PEG Linkers Poly PEG BroadPharm provides functionalized Poly PEGs with various active groups, including alkyne, carboxylic acid, amine, hydroxyl, thiol, azide, NHS ester, Acrylate, aldehyde, etc. Mac os server download. The following Poly PEGs are available at BroadPharm. Click the catalog number to see purity specifications and property information.

Recently developed lipid nanoparticle (LNP) formulations of siRNA have proven to be effective agents for hepatocyte gene silencing following intravenous administration with at least three LNP-siRNA formulations in clinical trials. The aim of this work was to develop LNP-siRNA systems for hepatocyte gene silencing that can be administered subcutaneously (s.c.). Three parameters were investigated, namely LNP size, residence time of the polyethylene glycol (PEG)-lipid coating and the influence of hepatocyte-specific targeting ligands. LNP sizes were varied over the range of 30 to 115 nm in diameter and PEG-lipid that dissociates rapidly (PEG-DMG) and slowly (PEG-DSG) were employed. In mice, results show that large (~80 nm) LNP exhibited limited accumulation in the liver and poor Factor VII (FVII) gene silencing at 1mg siRNA/kg body weight. Conversely, small (~30 nm) LNP systems showed maximal liver accumulation yet still had minimal activity. Interestingly, intermediate size (~45 nm) LNP containing PEG-DSG exhibited nearly equivalent liver accumulation as the smaller systems following s.c. administration but reduced FVII levels by 80% at 1mg siRNA/kg body weight. Smaller systems (~35 nm diameter) containing either PEG-DMG or PEG-DSG were less active; however addition of 0.5 mol.% of a GalNAc-PEG lipid to these smaller systems improved activity to levels similar to that observed for the ~45 nm diameter systems. In summary, this work shows that appropriately designed LNP-siRNA systems can result in effective hepatocyte gene silencing following s.c administration.

Peg2000 C Dmg

Peg

Peg Mgf Cycle

  1. Diacylglycerol-PEG / SUNBRIGHT® GM-020(DMG-PEG) 1 of 8. SUNBRIGHT® GM-020(DMG-PEG) $ 176.00. Package size: 1g amber glass bottle 10g aluminum pouch (+ $ 1,414.00) CODE: Availability: In stock Quantity: Add to Cart Add to comparison list. Description; Product inquiry; Acronym: DMG-PEG 2,000.
  2. Dimyristoyl glycerol (DMG) molecule associates with membrane similar to phospholipids. Structure, molecular formula and formula weight are representative of the average polymer length of the material. Application DMG-PEG 2000 is suitable for use in the preparation of lipid nanoparticle for microRNA and short interfering RNA delivery.
  3. These products lack phosphorylethanolamine groups and the extra linkage is relatively more stable against hydrolysis. Furthermore, because of.
  4. Creative PEGWorks’ PEG products include structurally and functionally diversified derivatives of linear methoxypolyethylene glycol, branched polyethylene glycol crosslinker, and multi-arm PEGs with a broad range of molecular weight from 100 (oligomers) to 125,000 (125k) Dalton.
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  6. PEG-20 Methyl Glucose Sesquistearate HLB = 15 PEG-25 Hydrogenated Castor Oil HLB = 10.8 PEG-30 Dipolyhydroxystearate HLB = 5.5 PEG-4 Dilaurate HLB = 6 PEG-40 Sorbitan Peroleate HLB = 9 PEG-60 Almond Glycerides HLB = 15 PEG-7 Olivate HLB = 11 PEG-7 Glyceryl Cocoate HLB=10 PEG-8 Dioleate HLB = 8 PEG-8 Laurate HLB = 13.